How GLP-1s help with insulin resistance
Insulin resistance is when your body doesn’t respond to insulin effectively, which leads to uncontrolled blood sugar levels and the development of type 2 diabetes.
But more than this, insulin resistance can damage your brain too, contributing to ND. Your brain needs insulin to create new neuronal connections to support memory and learning, and without it, inflammation can increase, damaging neurons, affecting your memory and ability to function.
GLP-1 RAs can enhance insulin sensitivity, which may improve cognitive function. It also has anti-inflammatory properties that may help reduce brain inflammation and slow the progression of ND.
How GLP-1s could help neuronal survival
GLP-1s have been shown to have neuroprotective properties, including:
- Reducing nerve cell death, which prevents cognitive decline.
- Promoting the growth of neurons to help build new connections.
- Improving motor and sensory function.
- Decreasing brain inflammation.
- Increasing blood flow to the brain to provide essential nutrients and oxygen.
These mechanisms may help neurons survive and improve overall brain function. As a result, GLP-1 agonist medications may also help to bring about these benefits (by performing the same functions within your body).
How GLP-1s help neuronal inflammation
Brain inflammation plays a key role in the development of ND. Although inflammation can be a neuroprotective property, chronic inflammation can cause neuronal damage and death.
Brain inflammation is believed to be caused by amyloid plaques, which are a hallmark of Alzheimer's disease (AD).
Studies show that GLP-1 has anti-inflammatory effects, reduces the accumulation of amyloid plaque, and enhances memory function.
