Tadalafil
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Reviewed on February 18, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
February 18, 2028.
Dr Alexandra Cristina Cowell

Last updated on Feb 18, 2025.

ED treatment that lasts 36 hours.

Tadalafil is the generic version of Cialis. It works within 30 to 60 minutes and can last up to 36 hours.

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$185.95
  • Prices include:
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    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

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What EXACTLY is TADALAFIL? And Why Should You Care? With Dr Daniel Atkinson | Choose Better Video play icon
Tadalafil Tadalafil

What is Tadalafil?

Tadalafil is an erectile dysfunction (ED) pill that helps you achieve an erection. It’s the generic version of Cialis, making it more affordable.

Tadalafil works by increasing blood flow to your penis, helping you get and maintain your erection when you become aroused.

How long does Tadalafil last?

There are two versions of tadalafil: daily and on-demand. The daily pill (2.5mg or 5mg) is taken every day, so you’re always ready to go.

The on-demand pill (10mg and 20mg), however, is taken before you have sex and can last up to 36 hours. This is great for men planning to have sex multiple times over a few days.[1]

Does Tadalafil have side effects?

Yes, you might experience side effects when taking Tadalafil. Some of the most common ones include headache, back pain, muscle aches, facial flushing and nasal congestion.

If your side effects persist or become unmanageable, let your doctor know.

What doses of Tadalafil are available?

Tadalafil is available in 4 doses: 2.5mg, 5mg, 10mg and 20mg. The recommended starting dose is 10 mg, which can be increased to 20 mg if the 10 mg dose is ineffective.

The 2.5 mg and 5 mg doses are intended for daily use for men who require ED treatment frequently.

How does Tadalafil compare with Sildenafil?

Tadalafil and Sildenafil are both drugs called PDE5 inhibitors, so they work in pretty similar ways. But where tadalafil’s effects last up to 36 hours,[1] sildenafil only works for around 3-5 hours.

A meta-analysis comparing Tadalafil and Sildenafil found that while both treatments were similarly effective, more people preferred Tadalafil over Sildenafil.[2]

How is Tadalafil different from Cialis?

Tadalafil and Cialis are essentially the same medication with different branding. Cialis is the branded version of Tadalafil, making it slightly more expensive.

Aside from the price, the manufacturer and packaging will also vary. However, both drugs work in the same way and have the same effectiveness, so you shouldn’t notice much difference.

Treated trusted source:

  1. Research, C. for D.E. and (2018). Questions and Answers for Cialis (tadalafil). FDA.
  2. Gong, B., et al (2017). Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: A systematic review and meta-analysis. International Urology and Nephrology, 49(10), 1731.
treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 18, 2025. Next review due on February 18, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Tadalafil Tadalafil

How to take Tadalafil on-demand (10mg or 20mg)

Swallow one Tadalafil tablet whole with water. Ideally, you should take an hour before you plan to have sex to give it time to start working.

Never take more than one pill in any 24 hours. If you find the tablet isn’t working for you, let your doctor know.

How to take daily Tadalafil (2.5mg or 5mg)

Swallow one Tadalafil tablet whole with water at the same time each day. It’s best to take Tadalafil one hour before you plan to have sex as it takes 30 to 60 minutes to work.

treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on February 18, 2025. Next review due on February 18, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Tadalafil Tadalafil

Tadalafil isn’t the best choice for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Tadalafil Tadalafil

Tadalafil: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

What should I do if Tadalafil doesn’t work?

Answer:
There are some things you can do to help Tadalafil work better, like:

  • Limit your alcohol intake

  • Exercise regularly

  • Take it with smaller meals


Sometimes, though, it might be that you need a higher dose or different medication. If you’re having any problems, let your doctor know and they’ll discuss it with you.

Do I need a prescription for Tadalafil?

Answer:
Yes. Tadalafil is only available with a prescription from your doctor. They’ll ensure it’s safe and suitable for you by asking a few questions about your health, medical history, and preferences before prescribing it.

How effective is Tadalafil?

Answer:
During clinical trials for Tadalafil, 81% of men reported an improvement in their erections, including 86% of men with mild ED symptoms and 72% of men with severe ED.[1]

In another study, results found that 70% of attempts at sexual activity were successful from 30 minutes to 36 hours using Tadalafil.[2]

How does Tadalafil work?

Answer:
Tadalafil belongs to a class of medications known as PDE5 inhibitors. PDE5 is an enzyme that causes your blood vessels to narrow and constrict.

Tadalafil inhibits the action of PDE5, which increases blood flow to your penis by relaxing tight blood vessels. This fills the muscle tissue in your penis with blood, making it firm and erect. But to get and maintain a firm erection, you will need to be sexually stimulated.

Treated trusted source:

  1. Electronic Medicines Compendium (n.d) Pharmacological properties – 5.1. Tadalafil 10mg film-coated tablets – Summary of Product Characteristics (SmPC) – (emc).
  2. Coward, Robert M.,et al (2008). Tadalafil in the treatment of erectile dysfunction. NCBI,  Ther Clin Risk Manag. 2008 Dec; 4(6): 1315–1330.

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AI Overview

Tadalafil is generally highly effective for erectile dysfunction, lasting up to 30 hours for some. Some users experienced mild side effects like headache, flushing, or stuffy nose, while others had no side effects. A few reported it didn't work for them or wasn't as strong as other brands. Some users found the lower dose (5mg) sufficient.

See all our reviews  

Read more about Tadalafil

Further reading

Take a look at our helpful health guides related to erectile dysfunction.

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