Levalbuterol is a rescue inhaler that works as a bronchodilator to open up your airways when you’re having an asthma attack. You can also take it half an hour before you exercise to keep asthma symptoms from developing. The effects of Levalbuterol last for an average of three hours but can go on for up to six hours.[1]
Levalbuterol is the generic version of Xopenex, so even though it’ll work essentially the same way, you can get it for a lower price. It contains a derivative of albuterol, which is the active ingredient in other inhalers such as Ventolin, ProAir, and Proventil.
Rescue inhalers are the kind of inhaler that you need to have with you at all times in case you get an asthma attack. If you use another type of inhaler, known as a preventer inhaler, you’ll need to use both – the preventer every day, and the rescue during the onset of symptoms.[2]
How does Levalbuterol work?
The active ingredient in Levalbuterol belongs to a class of drugs known as Beta-2 agonists, which keep the soft tissue in your airways from contracting, keeping your airways open, and improving asthma symptoms by making it easier for you to breathe.
It’s also thought that Beta-2 agonists have anti-inflammatory properties that can help you in the long-term, such as reducing the severity of your asthma symptoms.[3]
What doses of Levalbuterol are there?
Since Levalbuterol is an on-demand treatment, there isn’t a set dose: you should take it whenever you feel asthma symptoms developing (or before exercising). You can take up to two puffs, four times a day. Each puff delivers 59 micrograms of albuterol tartrate.
You should never exceed the maximum recommended dose, so if you find that two puffs every four to six hours are not enough, you should speak to your clinician so they can prescribe you a different rescue inhaler, a preventer inhaler, or tweak your preventer inhaler dose if you’re already using one.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Daniel Atkinson on January 29, 2025. Next review due on January 29, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to use Levalbuterol
The clinician who prescribes Levalbuterol to you will be able to give you instructions on how to use it properly, as well as tell you the maximum dose you can take in a day, and what to do if you need help. You should always follow their directions, but here’s a few general guidelines you can follow too:
Always shake the inhaler well for five seconds before each use. If you’re using it twice in a row, you need to shake it before your second puff as well;
If you’re using the inhaler for the first time, you haven’t used it for over two days, or you dropped your inhaler, you need to do four test puffs. You just need to press the canister four times in the air, away from your face. Try to hold it far away from you to avoid getting it on your eyes;
If you’re taking two puffs in a row you need to wait at least one minute between each puff;
Take off the mouth cap, breathe out as much as you can, and place the mouthpiece between your lips. Afterward, breathe in and press down the canister slowly, and at the same time. Then hold your breath for ten seconds and exhale slowly;
Put the mouth cap back on the inhaler and store it in a dry, room temperature place, with the mouthpiece pointing downwards.
How long does it take Levalbuterol to work?
If you’re using Levalbuterol to prevent asthma symptoms from developing during exercise, you should aim to take it 15-30 minutes before you begin.
If you’re using Levalbuterol to treat asthma symptoms as-and-when they happen, you should feel significant relief from five to ten minutes after you use it, but it can take over an hour for the drug to reach its full effectiveness. The benefits of Levalbuterol may last at least three hours, but they can go on for up to six hours.
What should I do if I make a mistake when using Levalbuterol?
Since Levalbuterol is an on-demand treatment, you can’t exactly miss a dose, but you might forget to take it with you when you leave the house and end up needing it. To avoid this, you can always keep your inhaler in the handbag you use daily or next to an item that you always take with you when you leave the house, such as your wallet or car keys. This will prevent you from going anywhere without it, and you will always know where it is.
If you accidentally take too much Xopenex, you should seek emergency medical attention so your symptoms can be treated as they occur. The symptoms of an overdose might include but are not limited to, nausea, dizziness, heart palpitations, headaches, tremors, arrhythmia (irregular heartbeat), dry mouth, fatigue, and insomnia.[1]
Treated trusted source:
Dailymed (n.d.). Levalbuterol Tartrate HFA inhalation. Drug label information.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr Daniel Atkinson on January 29, 2025. Next review due on January 29, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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There are some things you need to watch out for when using Levalbuterol, and not everyone can use it.
Here’s the official safety info. If there’s something you’re not sure about, let us know.
LevalbuterolLevalbuterol
Levalbuterol: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
Is Levalbuterol similar to any other treatments?
Answer:
Levalbuterol is the generic version of Xopenex, and while both have the same active ingredient and will work similarly in the body, Levalbuterol is likely to be the cheaper option.
The active ingredient in Levalbuterol, albuterol tartrate, is quite similar to albuterol sulfate which is found in a lot of inhalers, such as Ventolin, ProAir, and Proventil. The differences between these will mainly be in the side effects list, but when it comes to effectiveness, they all work similarly.[1]
How is Levalbuterol different from other inhalers for asthma?
Answer:
Levalbuterol is a rescue inhaler that you should take once asthma symptoms develop, or right before exercising to keep them from developing. But there are also steroid preventer inhalers that you take every day, even if you’re not having symptoms. In some cases, you might only need a rescue inhaler, but if your symptoms are severe and you’re experiencing them regularly, you might need to use both a preventer and a rescue inhaler.
Levalbuterol is button-activated, so you need to breathe in and push down the canister slowly, and at the same time. Some other inhalers are breath-activated, which makes them easier to use.
Which dose of Levalbuterol should I use?
Answer:
Levalbuterol is an on-demand treatment, so there’s no set regular dose that you should be taking at a set time. It’s a rescue inhaler, so you should use it whenever you’re experiencing asthma symptoms, and if you want, 30 minutes before you exercise to prevent any symptoms from developing. You can take up to two puffs, four times a day.
But if you find yourself needing to take this much twice a week or more, you should speak to the clinician who prescribed it so they can recommend a good preventer inhaler to take alongside your rescue one. If you already use a preventer inhaler and still need to use your rescue one regularly, the clinician might then tweak your dose to decrease the frequency of your asthma symptoms.
Do I need a prescription for Levalbuterol?
Answer:
Yes, you do need a prescription to get Levalbuterol. A clinician will want to assess your health needs and circumstances before you start taking any rescue inhaler to make sure that it’s the right medication option for you. If it is, they will prescribe it and dispense it to you. And if it’s not, they’ll explain your other treatment options and recommend the best one for you to try.
The clinician who prescribes the medication to you will also need to monitor your asthma symptoms to ensure the inhaler is working as well as it should, and if not, prescribe you something different that might work better.
How effective is Levalbuterol?
Answer:
Clinical trials have shown that Levalbuterol is highly effective in the treatment of acute asthma symptoms compared to placebo, with benefits lasting for as long as six hours after use of the inhaler. Another study proved that Levalbuterol is also much more effective than a placebo when it comes to preventing asthma symptoms from developing during exercise.[2]
Treated trusted source:
Brunetti, L., et al (2015). Clinical outcomes and treatment cost comparison of levalbuterol versus albuterol in hospitalised adults with chronic obstructive pulmonary disease or asthma. American Journal of Health-System Pharmacy, 72(12), pp.1026–1035.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Jan 28, 2025
Published by: The Treated Content Team.Medically reviewed by: Dr Daniel Atkinson, Clinical Reviewer
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Dr Daniel Atkinson
Clinical Reviewer
Dr Daniel is a UK doctor who reviews medical content across the site to make sure it's clinically accurate. On specific pages he's reviewed you'll see his reviewer card.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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