VerifiedFact Checked
Can weight loss injections help with menopausal symptoms?

Can weight loss injections help with menopausal symptoms?

Weight gain is a common symptom of menopause. Slower metabolism and body composition changes are a couple of reasons for this, but there are others too.

Weight loss injections (WLIs) may help with menopause symptoms by reducing weight gain, improving insulin sensitivity and enhancing metabolic health. Let’s find out how.

Alexandra Cristina Cowell
Medically reviewed by
Alexandra Cristina Cowell, Writer & Clinical Content Reviewer
Go to
Medically reviewed by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
on Jun 03, 2025.
Meet Alexandra Cristina  
Alexandra Cristina

Last updated on Nov 14, 2025.

Was this article useful?
Summary
  • Menopause tends to slow your metabolism and cause weight gain, especially around the belly.
  • Weight loss injections reduce food cravings and help you feel more full, making it easier to manage your weight during menopause.
  • Weight loss injections can improve insulin sensitivity, helping your body manage blood sugar.
  • Weight loss injections can work better with MHT (menopausal hormone therapy). Some women lose more weight with both than with either injections or MHT alone.

How can menopause affect your weight?

“Our body mass index (BMI), the ratio of our weight to height squared, naturally increases as we age. For many women this increase accelerates a little during perimenopause. This is partly due to changing hormone levels and, for lots of women, the changing demands of family life and career that often happen around this time.” – Dr Daniel Atkinson.

On average, women gain around 22 pounds (10kg) from perimenopause to menopause. And around 50% of perimenopausal women will experience some weight gain.

There are many reasons why women gain weight during this period, but here are some of the main ones:

Slower metabolism

As you get older, your metabolism naturally slows down. But in menopausal women, this can happen at a faster rate because of lower estrogen levels.

Estrogen plays a significant role in helping to control appetite, energy levels and body fat. It sends signals to your brain to boost physical activity and encourages your body to burn more energy.

Low estrogen levels can make you less motivated to be physically active, slowing the rate at which you burn calories, and increasing fat storage; all of which slow your metabolism.

Changes in body composition

Menopausal women tend to have more fat and less muscle mass. Estrogen controls how your body stores fat, and low levels cause more fat to be stored, especially around your abdomen and hips.

Estrogen also promotes the production of muscle tissue and prevents it from breaking down. When estrogen levels drop, this process is disrupted, leading to muscle loss and possibly sarcopenia – a condition characterized by age-related loss of muscle mass.

Since muscle burns up to three times more energy than fat, losing muscle mass can slow your metabolism, causing weight gain.

Sleep problems

While menopause doesn’t directly cause sleep issues, up to 47% of perimenopausal women and 60% of postmenopausal women have reported problems with sleep. Symptoms like night sweats, hot flashes and headaches can make it difficult to get good quality sleep.

Without proper sleep, your body can't function optimally, leading to unbalanced hormones and dysfunctional bodily processes.

Insufficient sleep can make you feel hungrier, too, as your levels of ghrelin (a hormone that increases appetite) go up. This often results in overeating and heightens your cravings for high-calorie, unhealthy foods.

And lastly, a lack of sleep can affect your metabolism, making it harder to burn calories and increasing fat storage. It’ll also make you more tired during the day, so you're less motivated to exercise.

Unregulated blood sugar levels

A study found that mice used less oxygen and burned less energy without estrogen, which led to weight gain and increased levels of body fat. When estrogen was then given to the same mice, they burned energy more efficiently and had improved insulin sensitivity.

Improved insulin sensitivity equals better blood sugar control. When your blood has excess sugar, most of the sugar is stored as fat, so you're more likely to gain weight.

What are weight loss injections?

WLIs often contain GLP-1 receptor agonists, which can help curb your hunger and decrease your appetite, helping you lose weight.

There are several types of weight loss injection, including:

  • Wegovy
  • Zepbound
  • Saxenda

Wegovy contains semaglutide, a GLP-1 receptor agonist. It decreases feelings of hunger, slows stomach emptying and improves blood sugar control, which helps you lose weight.

It comes in 5 doses: 0.25mg, 0.5mg, 1mg, 1.7mg and 2.4mg, and is injected weekly.

Studies have shown that taking semaglutide can help you lose up to 15% of your body weight in 6 months.

Zepbound contains tirzepatide, which is a GIP and GLP-1 receptor agonist. This dual effect makes it more effective than Wegovy. It works by making you feel fuller for longer and regulating your blood sugar levels.

It comes in 6 doses: 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg and 15 mg, and is injected weekly.

In a study that lasted 72 weeks, participants taking 15 mg doses of Zepbound lost an average of 20.9% of their starting weight, compared to only 3.1% in the placebo group.

Saxenda contains liraglutide, which is a GLP-1 receptor agonist. It controls your hunger, makes you feel fuller, decreases your appetite and manages your blood sugar levels.

It’s available in 5 doses: 0.6mg, 1.2mg, 1.8mg, 2.4mg and 3.0mg, and is injected daily.

In one study, people using Saxenda for 6 months lost 7.1% of their starting weight.

How do weight loss injections affect menopause?

WLIs can help improve symptoms of menopause and reduce your risk of developing conditions such as heart disease, osteoporosis and diabetes.

Some of their benefits include:

Weight loss

Weight loss injections work by reducing your appetite, which can increase during menopause, helping you lose weight.

Although menopausal weight gain is often caused by low estrogen levels, WLIs can help in other ways, especially when used alongside MHT.

A study found that women who used semaglutide alongside MHT lost 30% more weight on average than those who didn’t use MHT.

But it’s important that you do strength training exercises several times a week while using WLIs. Although WLIs can help you lose body fat, muscle mass is often lost too. This can increase your risk of sarcopenia, a condition characterized by muscle degeneration. Regular strength training can help prevent this issue and improve your overall health.

Improved metabolic function

WLIs increase insulin sensitivity, which improves how your body processes and stores sugar. Regulating your blood sugar levels can improve your metabolic health.

Research has shown that people using WLIs experience improvements in blood pressure, insulin levels, and cholesterol levels. These improvements have a positive impact on your cardiometabolic health and reduce cardiovascular risk.

Blood sugar regulation

Menopause can make cells less responsive to insulin, causing high blood sugar levels. WLIs can improve insulin sensitivity, meaning your body uses sugar better and stores less fat.

Regulating your blood sugar levels also decreases your chances of gaining weight and improves your overall health. It also improves blood sugar and energy levels, helping you fight fatigue, a common menopause symptom.

Can weight loss injections help with my menopause symptoms?

Weight loss injections aren’t a ‘magic fix’ for all menopause symptoms, but they might improve your overall health if you have obesity or overweight. You’ll also need to use them long-term to see significant health benefits, and may experience side effects while on them.

Some menopausal women may also notice better benefits when using them alongside MHT. It’s best to discuss all of this with your doctor, so you can decide together which treatment plan is best for you.

Reference Popover #ref1
Reference Popover #ref2
Reference Popover #ref3
Reference Popover #ref4
Reference Popover #ref5
Reference Popover #ref6
Reference Popover #ref7
Reference Popover #ref8
Reference Popover #ref9
Reference Popover #ref10
Reference Popover #ref11
Reference Popover #ref12
Reference Popover #ref13
Reference Popover #ref14

Sourcing guidelines:

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Tell us what you want to hear.

Have a subject you’d like us to cover in a future article? Let us know.

Give us the inbox treatment.

We're making healthcare more about you. Sign up to our newsletter for personalized health articles that make a difference.

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

Suggest a health guide

Tell us your idea here.

(And leave your email too, so we can let you know if we write an article based on your suggestion.)