Tri-Sprintec
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0.18mg - 0.215mg - 0.25/0.035mg
$81.95
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Reviewed on June 05, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
June 05, 2028.
Dr Alexandra Cristina Cowell

Last updated on Jul 01, 2025.

Birth control pill with phased hormone doses.

Tri-Sprintec is a birth control pill with changing hormone levels that can help to manage acne and menstrual symptoms. It comes in a 28-day pack and is more than 99% effective when used correctly.

Price checker
0.18mg - 0.215mg - 0.25/0.035mg
$81.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $81.95
    Save $0.00 each order
Tri-Sprintec Norgestimate/Ethinyl Estradiol

What is Tri-Sprintec?

Tri-Sprintec is a combined birth control pill that contains synthetic versions of progesterone and estrogen. It delivers a changing hormone dose across three weeks, followed by a week of inactive pills. It’s taken daily with no break between packs.

How does Tri-Sprintec work for birth control?

Tri-Sprintec works to prevent pregnancy by stopping ovulation, thickening cervical mucus, and thinning the uterine lining. This also means you might get lighter, more regular periods. You’ll take gray, light blue, and blue pills for 21 days, followed by 7 white placebo pills.

What’s the difference between Sprintec and Tri-Sprintec?

Tri-Sprintec is a multiphasic pill, so the hormone levels change throughout the pack. It has three different phases of hormones. Some people find multiphasic pills help reduce side effects as they mimic your natural cycle more closely.

Sprintec is monophasic, so it has the same dose of hormones throughout.

treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on June 05, 2025. Next review due on June 05, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Tri-Sprintec Norgestimate/Ethinyl Estradiol

How to take Tri-Sprintec tablets

Take one pill each day, at the same time every day, in the order shown on the pack. If you start taking it on day one of your period, you’ll be protected. If you start later, use backup protection (like condoms) for seven days.

What if I miss a Tri-Sprintec pill?

If you miss two pills in the first two weeks of the cycle, take two pills for two days, then continue as usual. You should use a barrier method of protection for the next week.

If you miss three or more active pills in a row, start a new pack and use a barrier method of protection for the next week.

If you miss any inactive pills, you can just throw them away and carry on as usual.

treated.com This page was written by The Treated Content Team.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on June 05, 2025. Next review due on June 05, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Tri-Sprintec Norgestimate/Ethinyl Estradiol

There are some things you need to watch out for when taking Tri-Sprintec, and not everyone can use it.

Here’s the official safety info. If there’s something you’re not sure about, let us know.

Tri-Sprintec Norgestimate/Ethinyl Estradiol

Tri-Sprintec: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How effective is Tri-Sprintec?

Answer:
When taken correctly (every day at the same time), it’s over 99% effective at preventing pregnancy.

With typical use (missing a pill occasionally), the effectiveness lowers to around 91%.

How is Tri-Lo-Sprintec different?

Answer:
Tri-Lo-Sprintec has less estrogen than Tri-Sprintec, so it can be a better option if you're sensitive to estrogen. If you get side effects on Tri-Sprintec, a doctor might suggest switching to the “Lo” version.

Can I get Tri-Sprintec through private health insurance?

Answer:
Yes, most private health insurance plans cover birth control like Tri-Sprintec, but coverage can vary between plans. It’s best to check with your provider to make sure both the treatment and pharmacy are covered, before you order your treatment.

What do Tri-Sprintec pill colors mean?

Answer:
The different color pills in the pack correspond with different phases:

  • Days 1-7: Gray

  • Days 8-14: Light blue

  • Days 15-21: Blue

  • Days 22-28: White (placebo)

What is the generic name for Tri-Sprintec?

Answer:
Tri-Sprintec is technically a branded generic of Ortho Tri-Cyclen, which was the original drug approved by the FDA. Other branded generics containing the same combination of active ingredients in the same amounts include Tri-Linyah, Tri-Estarylla, Tri-Mili, Tri-Femynor, and Tri-VyLibra. A non-branded generic, called Norgestimate and Ethinyl Estradiol, is also available.

These pills work in the same way, but they might differ in how the pills look, packaging, manufacturer, and price.

Can you take Tri-Sprintec for acne?

Answer:
Yes, Tri-Sprintec can help with acne.[1] It's FDA approved as an acne treatment, but only for people who also need birth control. If you're not using it for contraception or can’t take the combined pill, talk to a doctor about other acne treatments.

Can I skip a period with Tri-Sprintec?

Answer:
You can, but check with a doctor first. To skip your period, start a new pack after three weeks of blue active pills, skipping the week of white inactive pills. This isn’t the standard way to take Tri-Sprintec, so get medical advice before doing it.

Does Tri-Sprintec cause weight gain?

Answer:
Around 2.5% of users report weight changes when taking the combined pill, but it’s unclear if that’s due to the pill itself. There’s little evidence that Tri-Sprintec causes weight gain or loss, but if you notice changes, speak to a doctor.[2]

Does Tri-Sprintec cause depression?

Answer:
Hormonal birth control can cause mood swings or low mood in some people. If you feel depressed or notice ongoing mood changes while taking Tri-Sprintec, talk to a doctor.

Will I get breast growth with Tri-Sprintec?

Answer:
It’s possible, some people do experience breast-related side effects. These usually settle after a few months. If you have breast swelling, pain, or tenderness that persists - or if you notice a lump or tissue changes - contact a doctor right away.

How is Tri-Lo-Sprintec different?

Answer:
There is a Tri-Sprintec Lo dosage for women who have a slight estrogen sensitivity. The pills are very similar, but the active pills in Tri-Lo-Sprintec have a little less estrogen. Women who use Tri-Sprintec but get mild estrogenic side effects may be recommended the “Lo” version by a doctor instead.

Estrogenic side effects are symptoms like nausea, swollen or tender breasts, or heavy menstrual bleeding.

Treated trusted source:

  1. Jaisamrarn, U., Et al. (2014). A comparison of multiphasic oral contraceptives containing norgestimate or desogestrel in acne treatment: a randomized trial. Contraception, 90(5), pp.535–541.
  2. Lindh, I, Et al. (2011). The long-term influence of combined oral contraceptives on body weight. Human Reproduction. 26(7), pp.1917–1924.

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Similar but different.

Combined pills: Here are your other options.

Apri
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Pill with a "regular" estrogen dose. Very similar to Isibloom and Viorele.

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Estarylla
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The same active ingredients as Sprintec in a different pill. Up to 99% effective.

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Junel Fe
Junel Fe Norethindrone Acetate/Ethinyl Estradiol

The inactive pills contain an iron supplement. Similar to Loestrin Fe and Blisovi Fe.

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Portia
Portia Levonorgestrel/Ethinyl Estradiol

A daily combined pill that helps prevent pregnancy. May make your period lighter and less painful.

0.15mg - 0.03mg
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Sprintec
Sprintec Norgestimate/Ethinyl Estradiol

Daily birth control that can help manage irregular periods and acne. Similar to Estarylla and Femynor.

0.25mg - 0.035mg
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$84.95
See this option
Vienva
Vienva Levonorgestrel and Ethinyl Estradiol

Daily birth control pill. A low-dose pill, so you’re less likely to get side effects.

0.1mg/0.02 mg
$81.95
$81.95
See this option
Yasmin blister
Yasmin Drospirenone/Ethinyl Estradiol

The same active ingredients as Yaz but with a little more estrogen.

$309.95
$309.95
See this option
Yaz
Yaz Drospirenone/Ethinyl Estradiol

Birth control that helps manage acne. Low-dose version of Yasmin.

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