Zoloft

What is Zoloft?

Zoloft contains the active ingredient sertraline, an antidepressant that’s used to treat depression, anxiety and PTSD. It’s also prescribed off-label for premature ejaculation (PE). This doesn’t mean it’s unsafe; rather, it means that the drug isn’t officially approved for PE. Typically, your doctor will only do this if they think it’s safe and effective for you.

PE is a common sexual condition affecting up to 30% of men. It’s defined by ejaculation occurring within almost one minute of vaginal penetration or being unable to delay it. This can be frustrating and make physical intimacy difficult.^[1]

By taking Zoloft, you can effectively treat PE, and improve your confidence with sexual intimacy. Many studies have found sertraline can significantly improve sexual satisfaction and experiences.^[2]

How does Zoloft work?

Sertraline, a selective serotonin reuptake inhibitor (SSRI), works by increasing the levels of serotonin in your brain. Serotonin is a chemical involved in various processes, including ejaculation. When serotonin is released at appropriate levels to ensure ejaculation occurs in a well-timed and controlled manner.

In individuals with PE, the released serotonin is absorbed too quickly, disrupting the timing of ejaculation. Sertraline helps by blocking the reabsorption of serotonin, allowing it to stay in the brain for a longer time. This extended presence of serotonin regulates and delays the process of ejaculation, effectively treating PE.^[3]

What doses of Zoloft are there?

Zoloft is available in three different doses, 25mg, 50mg and 100mg tablets. You’ll usually start on a low dose of 25-50 mg once a day and might take one to two weeks before gaining the full effects.^[4]

How to take Zoloft

Take a tablet with a glass of water, with or without food. It can be taken in the morning or evening – whichever suits you best. Just make sure it’s around the same time every day. If you find you’re struggling to sleep after taking Zoloft, it’s best to take it in the morning.

Avoid grapefruit while taking sertraline, as it can increase the levels of sertraline in your body and possibly cause side effects.

How long does Zoloft take to work?

While sertraline is absorbed within a couple hours, it can take one-to-two weeks for you to see the full benefit from it.^[1] (But this can vary person to person, as everyone responds to drugs differently.)

Does Zoloft have withdrawal symptoms?

Yes — you can get withdrawal symptoms after stopping Zoloft, especially if you suddenly stop or were on it for a while. This can include any of the side effects listed in the patient leaflet, such as anxiety, appetite changes, hot flushes and more. The symptoms are usually mild to moderate and should go away within a few days, but in some cases they can be more serious or prolonged.

If you wish to stop your treatment with Zoloft, let your doctor know, and they’ll gradually lower your dose to prevent the risk of getting withdrawal symptoms.

What should I do if I make a mistake when taking Zoloft?

If you accidentally took too much, contact your doctor straight away or go to your local emergency department. Taking too much can cause overdose symptoms, such as drowsiness, nausea and vomiting.

If you forget to take a dose, skip the missed dose and carry on with your normal schedule. Don’t take a double dose to make up for a missed one.