Xigduo ®
We’ll deliver to you in 2-5 days
Price checker
5mg/1000mg
$2,043.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $2,043.95
    Save $0.00 each order
Reviewed on January 03, 2025. by
Dr. Joseph Palumbo
Senior Medical Adviser
Registered with NPI (No. 1043478878)
Next review due on
January 03, 2028.
Dr. Joseph Palumbo

Last updated on Jan 03, 2025.

Product info

  • Xigduo is a dual-action diabetes treatment containing dapagliflozin and metformin.

  • Dapagliflozin blocks glucose absorption by kidneys and metformin reduces blood sugar.
  • Xigduo is typically taken twice a day with food.

Price checker
5mg/1000mg
$2,043.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $2,043.95
    Save $0.00 each order
Xigduo metformin, dapagliflozin propanediol

What are Xigduo tablets?

Xigduo tablets are a combined tablet that lowers your blood sugar. It’s designed for people with type two diabetes, to help you get your blood glucose under control.

As well as helping to get your blood sugar under control now, Xigduo can also help you lose weight and reduce your risk of future complications.

How do Xigduo tablets work?

Xigduo tablets have two active ingredients, dapagliflozin and metformin. Dapagliflozin is a type of medicine called an SGLT2 inhibitor. This means it blocks a protein called SGLT2 from working properly. This stops the kidneys from absorbing as much glucose, which lowers the amount in your blood.[1]

Metformin is one of a class of drugs called biguanides, which work by decreasing blood sugar production and stopping you from absorbing as much glucose from your food. Together, these drugs work together powerfully to lower blood sugar, helping you get your diabetes treatment on track.

What doses of Xigduo are there?

There are five sizes of Xigduo tablets:

  • 2.5 mg dapagliflozin/1,000 mg metformin
  • 5 mg dapagliflozin/500 mg metformin
  • 5 mg dapagliflozin/1,000 mg metformin
  • 10 mg dapagliflozin/500 mg metformin
  • 10 mg dapagliflozin/1,000 mg metformin

The usual dose is one tablet a day, in the morning with food. The exact dose you take will depend on your symptoms. So if the first dose you try isn’t enough to control your diabetes, go back and talk to your clinician about your dose, or message us.

Treated trusted source:

  1. Plosker, G., 2012. Dapagliflozin. Drugs, 72(17), pp.2289-2312.
treated.com This page was written by The Treated Content Team.
Dr. Joseph Palumbo
This page was medically reviewed by Dr. Joseph Palumbo on January 03, 2025. Next review due on January 03, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Xigduo metformin, dapagliflozin propanediol

How to take Xigduo tablets

Always follow your doctor’s advice on how to take Xigduo tablets. We can give you personalised guidance and answer any questions you might have when you order from us.

  • It’s best to take Xigduo in the morning with breakfast to reduce stomach discomfort.
  • Try to take Xigduo at around the same time everyday.
  • Using alarms and keeping a schedule can help.
  • Take Xigduo with half a glass of water, so the tablets are easier to swallow.
  • Don’t crush or chew the tablets.

How long does it take Xigduo tablets to work?

Xigduo’s full results can take a while to show. Dapagliflozin starts to work on your glucose levels a couple of hours after you take it, while metformin can take a few days to lower your blood sugar.

So although Xigduo will have an effect pretty quickly, you won’t see the full extent right away. When you order with us, we’ll check in with you during treatment to see how Xigduo is working for you.

What should I do if I make a mistake while taking Xigduo?

If you take too much Xigduo, it can cause serious side effects. Get medical attention right away. If you forget to take Xigduo at your usual time, just take it when you remember.

If it’s nearly time for your next dose, skip the missed one and just keep taking it as normal. Never double up on your dose to make up for forgetting a tablet. Don’t stop taking Xigduo without talking to your doctor.

treated.com This page was written by The Treated Content Team.
Dr. Joseph Palumbo
This page was medically reviewed by Dr. Joseph Palumbo on January 03, 2025. Next review due on January 03, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Xigduo metformin, dapagliflozin propanediol

Xigduo tablets aren’t suitable for everyone, and there are some things that you need to be aware of when taking them.

Some recent research shows that metformin, one of the ingredients in Xigduo, can affect the quality of sperm. Men who are actively trying to conceive should discuss with their diabetes doctor or nurse whether Xigduo is the right treatment for them.

Here’s all the official info on them. If anything is unclear, let our doctor know, and they can talk with you about it.

Xigduo metformin, dapagliflozin propanediol

Xigduo: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are Xigduo tablets similar to any other treatment?

Answer:
Dapagliflozin and metformin are both available as treatments for diabetes on their own. They both come in generic or branded forms, so which kind you pick is really up to you.

There are also other combined treatments containing either dapagliflozin or metformin. Canagliflozin works very similarly to dapagliflozin and is available with metformin in a tablet form, called Invokamet.

How effective are Xigduo tablets?

Answer:
Both of the active ingredients in Xigduo work well at reducing your blood sugar alone, so together they have an even more powerful effect.

One study into the effect of dapagliflozin and metformin together compared the efficacy of the dapagliflozin to a wide range of other treatments, like DPP-4 inhibitors, TZDs and sulphonylureas. When used with metformin, dapagliflozin was similarly effective at controlling blood sugar as other treatments. It showed the same or better results for lower blood sugar, and better results for weight loss.[1] So Xigduo can help you control your blood sugar as well as making it easier to control your overall health.

There are things you can do to make Xigduo even more effective, like trying to keep up a healthy lifestyle. Losing weight and having regular health check ups are an important part of managing your type two diabetes. Getting regular exercise will also help keep you healthy and manage your diabetes.

Do I need a prescription for Xigduo tablets?

Answer:
Yes, you can only get Xigduo tablets with a prescription. Xigduo tablets are only designed for people with type two diabetes to take. Your diabetes treatment will also vary depending on your individual health needs.

When you talk to us about your health, we can help you figure out the right treatment plan. If Xigduo is right for you, our doctors can write you a prescription and have your treatment delivered straight to your home.

Can you drink alcohol while taking Xigduo?

Answer:
You should avoid drinking too much alcohol while you’re taking Xigduo tablets. Drinking alcohol while taking Xigduo raises your risk of ketoacidosis, a potentially life-threatening condition. It can also lower the effects of your medication.

Alcohol can also make managing your diabetes more difficult, as drinking too much affects your overall health. It can also increase your risk of hypoglycaemia. You should make sure to never drink too much in one sitting, or drink too often.

Treated trusted source:

  1. Goring, S., Hawkins, N., Wygant, G., Roudaut, M., Townsend, R., Wood, I. and Barnett, A., 2013. Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: a systematic review and network meta-analysis. Diabetes, Obesity and Metabolism, 16(5), pp.433-442.

This is healthcare on your terms.

All from the comfort of your device. Get access to what you need, when you need it.

100% online

Ask questions and get expert recommendations, at the touch of a button.

Tailored choices

We'll narrow down some treatments for you to choose from based on your medical profile.

Secure shipping

Receive your treatment by express delivery, in discreet packaging.

Easy automatic refills

Set your own delivery schedule and pause or make changes any time you like.

See how it works

Your partners in health

Get to know our clinical team. They review our info, prescribe and dispense your treatments.

Dr. Joseph Palumbo

Senior Medical Adviser
Dr-Joseph

Registered with NPI (No. 1043478878)

Meet Joseph  

Dr. Rami Ahmed

Prescribing Clinician
Dr. Rami Ahmed (1)

Registered with NPI (No. 1376740092)

Meet Rami  

Mr Craig Marsh

Clinical Reviewer
Mr-Craig

Registered with GPhC (No. 2070724)

Meet Craig  

Dr Daniel Atkinson

Clinical Reviewer
Dr D,new

Registered with GMC (No. 4624794)

Meet Daniel  

Here’s what you had to say

  • Service reviews
Treated
4.45

Average rating based on 2113 reviews.

Our verification process
551

Very convenient and time saver makes things easier

A
551

Treatment is going great! Fantastic service.

T
551

Understood my needs. Worked very fast. Script showed up quickly. Very satisfied. Highly recommend.

A
551

Ordered 8/21 and arrived 8/24. Always great service.

A
551

All worked as planned.

A
551

Everything is working very well thank you so much

J
See all our reviews 

Read more about Xigduo

Further reading

Woman with pink top and dark hair exercising with boxing gloves on

How to exercise safely when you have asthma

Thankfully, exercising with asthma isn’t impossible. It can take a little bit of planning, but the…

December 19, 2025 Read more
Man wearing checked shirt with glasses and grey beard in garden centre

What is an asthma attack?

Knowing the signs of an asthma attack and what to do is really important if you or someone you know …

December 19, 2025 Read more
A younger woman in a yellow cardigan sits on a couch with an older man in a blue jumper. They're both looking at a book held by the younger woman, and she's pointing to the page

Can taking weight loss injections lower your risk of getting dementia?

Everything you need to know about Wegovy and how it may lower the risk of neurodegenerative diseases…

December 12, 2025 Read more

Give us the inbox treatment.

We're making healthcare more about you. Sign up to our newsletter for personalised health articles that make a difference.

Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.

Tell us about a problem

Accept the terms of use terms of use

What did you like about it?

What didn't you like about it?

I'm looking for
Popular searches:
Viagra Wegovy Finasteride Varenicline Zepbound