Xhance ®
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Reviewed on November 12, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
November 12, 2028.
Dr Alexandra Cristina Cowell

Last updated on Nov 12, 2025.

Nasal spray for chronic sinus inflammation.

Xhance (fluticasone) is a corticosteroid nasal spray that’s prescribed to treat chronic rhinosinusitis, both with or without nasal polyps. It helps reduce swelling and mucus build-up in your sinuses, making it easier to breathe.

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93mcg
$999.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

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    $999.95
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Xhance Fluticasone propionate

What is Xhance?

Xhance is a corticosteroid nasal spray that contains fluticasone propionate, that reduces inflammation in your nasal passages and sinuses. It’s prescribed to treat chronic sinusitis and nasal polyps, which can cause blocked sinuses, facial pain, and loss of smell.

Unlike standard sprays, Xhance uses a special exhalation delivery system (EDS); You blow gently into the mouthpiece while using the spray, which helps the medicine reach deeper into your nasal and sinus cavities.

How does Xhance work for sinusitis?

Xhance contains fluticasone, a corticosteroid that calms the inflammation in your sinus lining. When you use it, the medicine targets the swollen tissues inside your nose and sinuses, lowering the amount of mucus you produce, and opening blocked airways so you can breathe more easily.[1]

Xhance also has a special exhalation delivery system that can make it more effective than regular nasal sprays. By breathing out into the device as you use the spray, you help move the medicine upward and backward into your sinuses —, places ordinary sprays struggle to reach.[2]

Will I get side effects using Xhance?

Xhance, like all medicines, can cause side effects in some people.

The most common ones are:

  • Nosebleeds
  • Sore throat or irritation
  • Headache
  • Nasal burning or dryness

Rarely, corticosteroids can be absorbed into your bloodstream and affect your hormones, especially if used for long periods or at high doses.[1] If you notice vision changes, severe nosebleeds, or experience persistent irritation, talk to your doctor.

What doses of Xhance are there?

Xhance comes in a 93 microgram per spray strength. The usual dose for adults is one or two sprays per nostril twice a day, but it can vary depending on your symptoms and your doctor’s instructions.

Treated trusted source:

  1. PATIENT INFORMATION XHANCE ®. (n.d.).
  2. Messina, J.C., et al. (2019). A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol. Clinical Therapeutics, 41(11), pp.2343–2356.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 12, 2025. Next review due on November 12, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Xhance Fluticasone propionate

How to take Xhance

Shake the device gently before use. Blow your nose to clear it. Insert the nozzle into one nostril and place the mouthpiece in your mouth.

As you blow out through the mouthpiece, press the spray button to release the dose. Repeat for the other nostril.

Use it twice daily, at the same times each day if you can. Don’t skip doses, and don’t stop suddenly without speaking to a clinician.

What should I do if I take too much Xhance?

Using Xhance more often than prescribed is unlikely to cause serious harm, but overusing it may increase your risk of side effects like nasal irritation or nosebleeds. If you accidentally use too much at once, just continue from your usual schedule.

Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 12, 2025. Next review due on November 12, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Xhance Fluticasone propionate

Xhance isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Xhance Fluticasone propionate

Xhance: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How does Xhance compare with Flonase?

Answer:
Both Xhance and Flonase contain the same active ingredient - fluticasone propionate - but they deliver it differently.

Flonase is a standard nasal spray that mainly coats the front of your nasal passages and sinuses. Xhance uses an exhalation delivery system (EDS) to push medicine deeper into your sinuses as you breathe out through the device.

Studies show that Xhance provides a wider coverage and better reach into your sinus cavities, which helps relieve congestion and inflammation that regular sprays can miss.[1]

How effective is Xhance?

Answer:
Clinical trials show that Xhance is effective for chronic sinusitis, with or without nasal polyps. Studies show that most people notice a significant improvement in their nasal blockage, pressure, and discharge within four weeks. CT scans also showed that inflammation had reduced after 24 weeks of continued use.[2][3]

Xhance has also been shown to cut sinus flare-ups by more than half and improve sense of smell and overall quality of life. For many people, Xhance provided relief even when standard sprays or past sinus surgery hadn’t helped.[2]

For how long can I use Xhance?

Answer:
Xhance is meant for long-term management of chronic sinus inflammation. Your doctor will usually review your progress after a few months, then decide whether or not you need to stay on it.
Each Xhance device contains around 120 sprays, equating to roughly a month’s supply when used twice a day.

How long does Xhance take to work?

Answer:
Xhance can reduce congestion and facial pressure within a few days to weeks of starting treatment.[2] For full results, it can take around 24 weeks of consistent use.[3]

Is Xhance a steroid or an antihistamine?

Answer:
Xhance is a steroid nasal spray, not an antihistamine. It contains a corticosteroid called fluticasone, which works by reducing inflammation and swelling in your sinuses.

Unlike antihistamines, which block allergy symptoms, steroids like fluticasone work directly on inflamed tissue to ease congestion and sinus pressure.

Can I drink alcohol while using Xhance?

Answer:
Yes. Xhance acts locally in your nasal passages and doesn’t interact with alcohol.

That said, some studies show that drinking alcohol can worsen sinus symptoms and increase congestion, so practicing moderation might help you feel better overall.[4]

Can I get Xhance through private health insurance?

Answer:
Yes, many US insurance plans will cover Xhance with a prescription, but the amount of coverage and amount available can vary by provider and plan. Check your plan’s formulary to see what’s covered before filling your prescription.

Treated trusted source:

  1. Messina, J.C., Offman, E., Carothers, J.L. and Mahmoud, R.A. (2019). A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol. Clinical Therapeutics, 41(11), pp.2343–2356.
  2. Ow, R.A., et al. (2022). Efficacy of the exhalation delivery system with fluticasone in patients with chronic rhinosinusitis with nasal polyps whose symptoms recur after sinus surgery. International Forum of Allergy & Rhinology, 13(1), pp.31–41.
  3. Palmer, J.N., et al. (2024). Efficacy of EDS-FLU for Chronic Rhinosinusitis: Two Randomized Controlled Trials (ReOpen1 and ReOpen2). The Journal of Allergy and Clinical Immunology In Practice, 12(4), pp.1049–1061.
  4. Nihlen, U., Greiff, L.J., Nyberg, P., Persson, C.G.A. and Andersson, M. (2005). Alcohol-induced upper airway symptoms: prevalence and co-morbidity. Respiratory Medicine, 99(6), pp.762–769.

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