Metoclopramide
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Reviewed on November 13, 2025. by
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Dr Alexandra Cristina Cowell

Last updated on Nov 14, 2025.

Block signals to the nausea center of your brain.

  • Relieves nausea by blocking dopamine receptors in your brain.

  • Oral tablets can work in 30-60 minutes.
  • It’s an off-label treatment for vestibular neuritis (also known as labyrinthitis).

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Metoclopramide Metoclopramide

What is Metoclopramide?

Metoclopramide is an antiemetic, a type of medicine that’s used to prevent nausea and vomiting. There’s some evidence that it can help relieve dizziness and headaches associated with labyrinthitis, too.

Metoclopramide is an off-label treatment for nausea and vomiting caused by inner-ear conditions. ‘Off-label’ means that while it’s not been officially licensed for this purpose, it’s thought to be a safe and effective treatment nonetheless.

How does Metoclopramide work?

Metoclopramide blocks dopamine receptors in the area of your brain called the chemoreceptor trigger zone (CTZ). This area of your brain detects toxins in your body and then induces vomiting to clear the toxins out. By stopping signals from traveling to these receptors, Reglan should help to relieve feelings of nausea and prevent vomiting.[1]

Metoclopramide may also speed up how quickly food moves through your digestive tract, which may also help relieve nausea.

How do Metoclopramide doses work?

Metoclopramide comes in two doses: 5 mg and 10 mg tablets. How much you’ll take (and for how long) comes down to the condition you’re taking it for, and how severe your nausea is.

What is Metoclopramide’s active ingredient?

Metoclopramide is a generic medication that’s named after its active ingredient. It’s an antiemetic, which is a type of medicine used to help relieve and prevent nausea and vomiting.

Treated trusted source:

  1. Kaye, A.D. et al. (2025). The Pharmacological and Clinical Roles of Antiemetics: A Narrative Review. Cureus. 17(1).
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 13, 2025. Next review due on November 13, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Metoclopramide Metoclopramide

How to take Metoclopramide

Always follow your doctor’s instructions when using Metoclopramide. Typically, you’ll use it over a short period of time (around five days), and take 5-10 mg every eight hours during that time.[1] But it’s important to take metoclopramide exactly as your physician has directed.

Treated trusted source:

  1. Swartz, R. Longwell, P. (2005). Treatment of Vertigo. American Family Physician. 71(6). pp. 1115-1122.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 13, 2025. Next review due on November 13, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Metoclopramide Metoclopramide

Metoclopramide isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Metoclopramide Metoclopramide

Metoclopramide: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Are there any Metoclopramide alternatives?

Answer:
Yes, you’ve got a few options when it comes to treating nausea caused by inner-ear problems. If your nausea is mild, antihistamines like cinnarizine and cyclizine could be enough to help. They block the histamine receptors in your brain. Histamine is a neurotransmitter that can activate areas of the brain that control vomiting, so blocking these receptors can help prevent feelings of nausea. Cinnarizine can also improve blood flow to your inner ear, which can help ease dizziness as well.

If you’re looking for an alternative antiemetic, Reglan or prochlorperazine could be good options. Reglan is the branded version of metoclopramide, which means it contains the exact same active ingredient and works in the same way. Prochlorperazine, on the other hand, contains a slightly different antiemetic. It works in a very similar way to metoclopramide (by blocking dopamine receptors in your brain), but may be an effective alternative if metoclopramide has been ineffective.[1]

How effective is Metoclopramide?

Answer:
Metoclopramide is an off-label treatment for labyrinthitis, so the available data is limited. But metoclopramide has shown to be an effective treatment for nausea caused by inner ear conditions.

A study involving 200 people found that metoclopramide and dimenhydrinate were equally effective at treating nausea and vomiting symptoms caused by vertigo, with both groups experiencing improvements to their Visual Analogue Scale compared to baseline.[2]

Do I need a prescription for Metoclopramide?

Answer:
Yes. Metoclopramide is an off-label treatment, which means it isn’t officially licensed to treat vestibular neuritis or vertigo. A healthcare professional will need to check to make sure that it’s the best option for you.

How long does it take Metoclopramide to work?

Answer:
Metoclopramide tablets get to work right away, and you should notice their effects after about 30 to 60 minutes.[3]

What should I do if I make a mistake when taking Metoclopramide?

Answer:
If you take too much metoclopramide, get medical attention right away. Symptoms of metoclopramide overdose can include:

  • Uncontrollable movements

  • Drowsiness

  • Difficulty with consciousness

  • Confusion

  • Hallucinations

  • Heart problems


Never take a double dose of metoclopramide to make up for missing a dose.

Are there any Metoclopramide side effects?

Answer:
Metoclopramide comes with some risk of side effects, but they won’t affect everybody.

However, if you experience any of the following side effects, stop using metoclopramide and speak with your doctor right away:

  • Uncontrollable movements or muscle contractions

  • Parkinson’s-like symptoms (rigidity and tremor)

  • A fever

  • High blood pressure

  • Convulsions

  • Sweating

  • Producing more saliva

  • Itchy skin rash

  • Swelling in the face, lips, or throat

  • Difficulty breathing


Metoclopramide’s most common side effect, which affects over one in 10 people, is drowsiness. The next most common side effects, affecting up to one in 10 people, are:

  • Depression

  • Restlessness

  • Lowered blood pressure

  • Diarrhea

  • Weakness

Can I get Metoclopramide through private health insurance?

Answer:
Metoclopramide is sometimes covered by health insurance plans, but it’s always a good idea to check your health insurance plan’s formulary to see the treatments they cover. For example, your insurance may only cover certain brands of metoclopramide (like Reglan), or only if you get it from specific healthcare providers.

If you can’t get metoclopramide on your health insurance, you should still be able to obtain it from a private online pharmacy service. You’ll just need to fill out a consultation so a physician can check that it’s the right treatment for you.

Treated trusted source:

  1. South & West Devon Formulary and Referral. (2023). 4.6 Drugs used in nausea and vertigo.
  2. Ercin, D. et al. (2020). Comparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study. American Journal of Emergency Medicine. 40. pp. 77-82.
  3. NHS. (2023). Common questions about metoclopramide. NHS UK.

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