Meclizine
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Reviewed on October 09, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
October 09, 2028.
Dr Alexandra Cristina Cowell

Last updated on Oct 28, 2025.

Tablet for treating vertigo and nausea.

Meclizine is a first-generation antihistamine that helps control balance problems linked to inner ear disorders, including Meniere’s disease. It works by calming the signals in your inner ear that trigger spinning sensations and sickness, so you can get relief from dizziness and nausea.[1]

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$79.95
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  1. Houston, B.T. and Chowdhury, Y.S. (2022). Meclizine. PubMed.
Meclizine Meclizine

What is Meclizine?

Meclizine is an oral antihistamine tablet that reduces vertigo, nausea, and vomiting. It’s mainly used for conditions like Meniere’s disease, where inner ear problems cause sudden episodes of dizziness. It’s also prescribed for motion sickness and, sometimes, as an ‘off-label’ treatment for other balance and spatial disorders. ‘Off-label’ simply means outside of the medication’s official license. It’s a common practice among doctors when they’re confident the medication will be safe and effective for your particular condition.

Meclizine doesn’t cure Meniere’s disease, but it can make flare-ups easier to manage by easing your symptoms.[1]

How does Meclizine work for Meniere’s disease?

Meclizine blocks histamine (H1) receptors in your brain and inner ear, and also has mild anticholinergic effects (meaning it blocks the action of a neurotransmitter called acetylcholine, which contributes to your symptoms). Together, these actions calm down signals that cause vertigo, nausea, and vomiting. In Meniere’s disease, this helps reduce the intensity of sudden dizzy spells and makes the symptoms more manageable.[1][2]

Will I get side effects using Meclizine?

Like many antihistamines, meclizine can make you feel sleepy or drowsy. Other common side effects include dry mouth, headache, fatigue, or stomach upset. Most side effects are mild, but if they feel severe or don’t go away, let a clinician know.

People can also experience allergic reactions, or in rarer cases, blurred vision. If you experience this, seek medical advice. 

What doses of Meclizine are there?

Meclizine is available in 12.5 mg, 25 mg, and 50 mg oral tablets. The dose you’ll be prescribed depends on what you’re using it for. For Meniere’s disease and vertigo, it’s typically 25 mg or 50 mg.

Treated trusted source:

  1. Houston, B.T. and Chowdhury, Y.S. (2022). Meclizine. PubMed.
  2. Foster, C. (2015). Optimal management of Ménière’s disease. Therapeutics and Clinical Risk Management, p.301.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on October 09, 2025. Next review due on October 09, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Meclizine Meclizine

How to take Meclizine

Swallow meclizine tablets whole, with or without food. If you’re prescribed chewable tablets, make sure you crush or chew them completely before swallowing.

Follow your doctor’s instructions carefully, and don’t take more than prescribed.

What should I do if I take too much Meclizine?

If you think you’ve taken more than the recommended dose of Meclizine, you should call your local poison control center or seek medical help straight away.

Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on October 09, 2025. Next review due on October 09, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Meclizine Meclizine

Meclizine isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Meclizine Meclizine

Meclizine: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How does Meclizine compare with alternative treatments?

Answer:
Meclizine is one of the most commonly prescribed antihistamines for vertigo and Ménière’s disease. It works in a similar way to dimenhydrinate (Dramamine), which is also a first-generation antihistamine.

Some studies show benzodiazepines, like diazepam, are also effective for acute vertigo symptoms, but antihistamines like Meclizine are often preferred because they carry less risks of becoming dependent.[1]

No treatments can cure Meniere’s disease, but they aim to reduce attacks and the severity of your symptoms.

How effective is Meclizine?

Answer:
Clinical studies show that meclizine can provide significant relief from vertigo and nausea, the main symptoms of Meniere’s disease.[2] It doesn’t cure the condition or prevent hearing loss, but it can make your symptoms much easier to manage.

How long does Meclizine stay in your system?

Answer:
Meclizine’s half-life is about 6 hours, but the effects on your body can last anywhere from 8 to 24 hours. It will be different depending on your individual circumstances and the dose you’re using.[3]

How long does Meclizine take to work?

Answer:
Meclizine usually starts working within about an hour of taking it and reaches peak effect after around three hours.[3]

How often can you take Meclizine?

Answer:
For Ménière’s disease, a typical dose is 25 mg-50 mg daily. Always follow your prescriber’s instructions and don’t take Meclizine more often than directed.

Can I drink alcohol while using Meclizine?

Answer:
It’s best to avoid alcohol. Both alcohol and meclizine can make you feel sleepy and slow your reaction times, so combining them increases the risk of accidents and side effects.

Can I use Meclizine during pregnancy?

Answer:
Meclizine has been studied in pregnancy and is generally considered safe to use for nausea and vomiting. It’s a former FDA Category B drug, which means it hasn’t been linked to harm in unborn babies at normal doses.[3] Always check with your doctor before starting any new medication in pregnancy.

Is Meclizine available over the counter?

Answer:
In the US, some low-dose forms of meclizine are available over the counter for motion sickness, while higher doses (like those for Ménière’s disease) usually need a prescription.

Can I get Meclizine through private health insurance?

Answer:
You can get Meclizine through private health insurance plans in the US. That said, coverage can vary depending on your individual plan and provider, so it’s worth checking with your insurer.

Treated trusted source:

  1. Hunter, B.R., et al. (2022). Efficacy of Benzodiazepines or Antihistamines for Patients With Acute Vertigo. JAMA Neurology, 79(9), pp.846–846.
  2. Dyhrfjeld‐Johnsen, J. and Attali, P. (2019). Management of peripheral vertigo with antihistamines: New options on the horizon. British Journal of Clinical Pharmacology, 85(10), pp.2255–2263.
  3. Houston, B.T. and Chowdhury, Y.S. (2022). Meclizine. PubMed.

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