Doxycycline
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Reviewed on November 11, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
November 11, 2028.
Dr Alexandra Cristina Cowell

Last updated on Nov 12, 2025.

Oral antibiotics for bacterial sinusitis.

Doxycycline is an oral antibiotic that helps treat bacterial sinusitis. It’s taken twice daily for up to 10 days.

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100mg
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Doxycycline Doxycycline

What is Doxycycline?

Doxycycline is an antibiotic that helps treat bacterial sinusitis, a condition characterized by the swelling of the sinuses. This leads to a stuffy, blocked nose that can make breathing difficult. Sinusitis doesn’t always require treatment, but if your symptoms persist or worsen, you may need antibiotics (potentially alongside other treatments to help reduce inflammation).

How does Doxycycline work?

Doxycycline is from the drug class called tetracyclines. These medicines inhibit protein synthesis, preventing bacterial growth. This weakens the bacteria, making it easier to kill and treat infections.[1]

Will I get side effects with Doxycycline?

Yes, there’s a chance of getting side effects when taking Doxycycline, but not everyone will get them. The side effects might include:

  • Nausea
  • Vomiting
  • Heart inflammation
  • Heartburn
  • Vaginal infection

Taking Doxycycline with food or milk can reduce the risk of side effects like nausea. These side effects should go away once you stop taking it.

Is it safe to drink alcohol while taking Doxycycline?

You should avoid drinking alcohol while on Doxycycline, as it may interfere with how the medicine works and might increase the risk of side effects.

What doses of Doxycycline are there?

Doxycycline comes in one dose of 100mg. The typical dose is two tablets daily for up to 10 days.

Treated trusted source:

  1. Parmar M, Patel P. Doxycycline Hyclate. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 11, 2025. Next review due on November 11, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Doxycycline Doxycycline

How to take Doxycycline

Swallow Doxycycline whole with water. Take it while standing or sitting, and avoid lying down for at least 30 minutes after taking it.

You can take it with or without food, but taking it with food can help prevent side effects.

If you’re taking two tablets, take them separately in the morning and evening. It’s also best to take Doxycycline at the same time each day for best results.

Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on November 11, 2025. Next review due on November 11, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Doxycycline Doxycycline

Doxycycline isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Doxycycline Doxycycline

Doxycycline: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

How fast does Doxycycline work?

Answer:
Doxycycline starts to work in the body within a few hours, but it can take a couple of days to notice an improvement in your symptoms.

It’s important you finish the full course of antibiotics even if you think you're better. This is because stopping antibiotic treatment midway can cause the infection to return and sometimes make it more difficult to treat.

How does Doxycycline compare with other treatments for sinusitis?

Answer:
Doxycycline is one of several antibiotics recommended for treating bacterial sinusitis. The first-line treatment is usually amoxicillin, another antibiotic that works in a similar way to doxycycline, with both being effective options.

Your doctor might also suggest using nasal sprays such as nasal or Budesonide, which is a corticosteroid nasal spray. These sprays help relieve symptoms like nasal congestion, which makes it easier to breathe.

Can you take Doxycycline with food?

Answer:
Yes, you can take Doxycycline with food. Some doctors might even recommend it as it reduces the risks of side effects. It might also improve absorption, making it more effective for certain conditions.

Does Doxycycline have any interactions?

Answer:
Doxycycline can interact with certain medications, like antifungals, acne treatments, and alcohol. If you're taking any medicine, you should let your doctor know so they can check if it's safe for you to take.

Can I take Doxycycline while pregnant?

Answer:
No, you shouldn’t take Doxycycline while pregnant, as it can increase the risk of birth defects.

Can I get Doxycycline through private health insurance?

Answer:
Doxycycline might be available on private insurance, but it’s best to check with your insurance provider to confirm. Some health plans might only cover certain medications or specific brands.

If they don't cover it, you can still get it from Treated, but you’ll have to pay for it yourself.

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