Cycloset ®
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Reviewed on January 03, 2025. by
Dr. Joseph Palumbo
Senior Medical Adviser
Registered with NPI (No. 1043478878)
Next review due on
January 03, 2028.
Dr. Joseph Palumbo

Last updated on Jan 03, 2025.

Product info

  • Cycloset is a tablet treatment for type 2 diabetes.

  • It works by improving insulin sensitivity to help control blood sugar.
  • The starting dose is 0.8mg, which is usually increased to reach a maintenance dose.

Price checker
0.8mg
$1,319.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $1,319.95
    Save $0.00 each order
Cycloset Bromocriptine mesylate

What is Cycloset?

Cycloset is a tablet treatment for type 2 diabetes containing the active ingredient bromocriptine mesylate. Unlike other diabetes medicines, bromocriptine acts on the dopamine receptors in the brain to regulate insulin levels. While taking Cycloset, it’s recommended to follow a healthy diet and exercise to help lower blood sugar levels.

Type 2 diabetes happens when your body doesn’t produce enough insulin or is unable to use it effectively, leading to high blood sugar levels. It doesn’t always need treatment as it can be managed through exercise and diet alone. But in some cases, leaving it untreated can increase the risk of developing health conditions like heart disease and kidney failure. Cycloset can help manage blood sugar levels in people with type 2 diabetes.

How does Cycloset work?

Bromocriptine mesylate, the active ingredient in Cycloset, is a dopamine receptor agonist. It boosts early-morning dopamine activity, helping reset the body’s circadian rhythm. Dopamine plays an important role in metabolism and insulin sensitivity.

When the circadian rhythm is reset, it reduces insulin resistance, allowing the body to respond more effectively to insulin and aiding in blood sugar regulation.[1]

Unlike conventional diabetes treatments that increase insulin levels, Cycloset improves the effectiveness of insulin to help lower blood sugar.

What doses of Cycloset are there?

Cycloset is only available as a 0.8mg tablet. The starting dose is 0.8mg daily, which is increased by one additional tablet each week until the maximum daily dose of 1.6mg to 4.8mg is reached. Your doctor will help you determine the best dose for optimum blood sugar control.

Treated trusted source:

  1. Shivaprasad, C. and Kalra, S. (2011). Bromocriptine in type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 15(5), p.17.
treated.com This page was written by The Treated Content Team.
Dr. Joseph Palumbo
This page was medically reviewed by Dr. Joseph Palumbo on January 03, 2025. Next review due on January 03, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Cycloset Bromocriptine mesylate

How to take Cycloset

When taking Cycloset:

  1. Take one tablet daily with some water.
  2. It’s recommended to take it within 2 hours of waking up.
  3. It’s preferable not to take it on an empty stomach; eating before your dose can help reduce the likelihood of side effects.

Whilst you’re on Cycloset, your doctor will recommend that you follow a diet and exercise program to further help lower your blood sugar levels. The diet will usually focus on low-GI foods with varied vegetables, fruits, protein and wholegrains. In some cases, they may recommend you speak to a dietitian for specialist advice.

For adults (living with or without diabetes), the CDC recommends150 minutes of moderate exercise a week, in addition to strength training exercises on two days per week. Doing this can help you to control your blood sugar levels and improve your overall health.

How long does Cycloset take to work?

Cycloset works relatively quickly, typically within 60 minutes. When taken with food, the absorption is slightly delayed by approximately one hour, reaching peak concentration by 120 minutes.[1]

However, it may take several weeks to notice a difference in your blood sugar levels and several months to see the full benefits of the treatment.

What should I do if I make a mistake when taking Cycloset?

If you forget to take your dose one morning, skip the missed dose and continue with our schedule the next morning. Don’t take a double dose to make up for a missed one.

If you accidentally take too much, contact your doctor immediately. Your blood sugar could drop to dangerously low levels, so it’s recommended to get immediate medical attention if this happens.

Treated trusted source:

  1. Shivaprasad, C. and Kalra, S. (2011). Bromocriptine in type 2 diabetes mellitus. Indian Journal of Endocrinology and Metabolism, 15(5), p.17.
treated.com This page was written by The Treated Content Team.
Dr. Joseph Palumbo
This page was medically reviewed by Dr. Joseph Palumbo on January 03, 2025. Next review due on January 03, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Cycloset Bromocriptine mesylate

Cycloset isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.

Cycloset Bromocriptine mesylate

Cycloset: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Who is Cycloset for?

Answer:
Cycloset is only for people with type 2 diabetes. It can’t be used to treat type 1 diabetes or diabetic ketoacidosis.

It’s also not suitable for those with low blood pressure or have had a history of psychiatric disorders. If this applies to you, your doctor will recommend an alternative treatment.

Cycloset can also suppress lactation, so let your doctor know if you’re breastfeeding or pregnant. They may suggest an alternative treatment.

How does Cycloset differ from other diabetes medications?

Answer:
Cycloset is a dopamine receptor agonist that enhances the effectiveness of insulin to control blood sugar levels. This mechanism is different from traditional diabetes medications like Gliclazide, which increases insulin production.

Although the action of Cycloset is similar to that of Metformin—another medication that improves insulin response—the two work in different ways. Metformin activates post-receptor insulin signaling pathways to enhance insulin action. So, if you’ve tried Metformin and it didn't work well for you, trying Cycloset might be beneficial for you.

What are the side effects of Cycloset?

Answer:
Just like any other diabetes treatment, some people may experience side effects while taking Cycloset. Common side effects include:

  • nausea,

  • headaches,

  • dizziness,

  • vomiting,

  • fatigues, and

  • low blood sugar levels.


Taking it with food can help reduce side effects like nausea and drinking plenty of water can help with dizziness and headaches. It’s better to limit your alcohol intake while taking Cycloset, because combining the two might worsen side effects like dizziness.

If you’re finding it hard to manage the side effects or notice them worsening, contact your doctor. They’ll lower your dose or suggest an alternative treatment.

What does bromocriptine treat?

Answer:
Bromocriptine is a dopamine agonist that can be used to treat conditions, like Parkinson's disease and neuroleptic malignant syndrome, and to suppress lactation. It’s also used to treat type 2 diabetes.

In the late 2000s, researchers discovered that since dopamine influences insulin, bromocriptine could be effective in treating type 2 diabetes by regulating metabolism and improving insulin sensitivity.[2]

Is there a generic version of Cycloset?

Answer:
Currently, there are no generic versions or alternative brands of Cycloset; it‘s only available under the brand name Cycloset for diabetes.

You might find the active drug Bromocriptine as a generic medicine or under a different brand name like Parlodel, but these drugs are used to treat different conditions. They come in different doses and have slightly different chemical formulas.

For type 2 diabetes, the only FDA-approved medication containing bromocriptine is Cycloset.

Does Cycloset cause weight loss?

Answer:
Cycloset isn’t thought to cause weight loss or weight gain directly. In the clinical studies, participants using Cycloset for 24 weeks found minimal difference in their weight (a 0.2mg increase). This was similar to the placebo group, which has a 0.5mg increase in weight.[1]

Treated trusted source:

  1. Cycloset. FDA. (n.d.). [Accessed 25 Oct. 2024].
  2. Ralph A. DeFronzo; Bromocriptine: A Sympatholytic, D2-Dopamine Agonist for the Treatment of Type 2 Diabetes. Diabetes Care 1 April 2011; 34 (4): 789–794.

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