Bonine
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Reviewed on October 13, 2025. by
Dr Alexandra Cristina Cowell
Writer & Clinical Content Reviewer
Next review due on
October 13, 2028.
Dr Alexandra Cristina Cowell

Last updated on Oct 28, 2025.

Chewable tablets to treat vertigo and nausea.

Bonine is the branded version of Meclizine, an antihistamine that treats vertigo, nausea, and dizziness within an hour.

Price checker
25mg
$399.95
  • Prices include:
    Express shipping

    2-5 day shipping by secure courier

  • Consultation + Access to our clinicians

    Ask our experts anything you like, any time you want.

  • Total
    $399.95
    Save $0.00 each order
Bonine Meclizine

What is Bonine?

Bonine is an antihistamine that can treat three inner ear conditions: Ménière’s disease, labyrinthitis, and BPPV. Although FDA-approved to treat nausea associated with motion sickness, Bonine is prescribed off-label for the three conditions mentioned above. Off-label use simply means that the medication hasn’t been approved yet to treat certain conditions, but there’s enough evidence that the medicine is effective and well-tolerated.

While each condition is different, they share similar symptoms (like vertigo, nausea, and vomiting). These symptoms are caused by a common factor: histamine. By targeting this underlying cause, Bonine can help relieve these symptoms.

How does Bonine work?

Meclizine, the active ingredient in Bonine, is a first-generation antihistamine. It works by blocking histamine in the area of the brain that triggers nausea, dizziness, and vomiting. This restores balance within the inner ear and reduces feelings of vertigo.[1]

It also blocks the brain chemical acetylcholine, which plays a key role in the brain and inner ear in regulating balance and motion. This also contributes to its anti-vertigo effects.[1]

How does Bonine compare with Dramamine?

Bonine and Dramamine are two different, but very similar, treatments for inner ear conditions. Both treatments are antihistamines, but they contain different active ingredients. This means that while they work in similar ways, if one doesn’t work well for you, the other may be effective.

Additionally, Dramamine acts more quickly, taking effect within 30 minutes,[2] but its effects last for a shorter period of 4-8 hours.[3] Bonine, on the other hand, takes around one hour to start working but lasts for up to 24 hours.[4]

Is Bonine non-drowsy?

No, Bonine is a first-generation antihistamine that enters the brain and blocks histamine and acetylcholine, which can affect how alert you feel.[5] So you may get drowsy or sleepy as a result. If you become drowsy, don’t drive or operate heavy machinery.

What doses of Bonine are there?

Bonine is only available in one dose of 25 mg. You’ll usually take one tablet as required, but you can take two tablets if needed.

If you prefer a lower dose, you can get a generic Bonine in a 12.5 mg dose.

Treated trusted source:

  1. Houston, B.T. and Chowdhury, Y.S. (2022). Meclizine. PubMed.
  2. Dramamine®. (2025). Frequently Asked Questions.
  3. DRUGBANK (2025). Dimenhydrinate. go.drugbank.com.
  4. Patel, P. N., & Ambizas, E. M. (2011). Meclizine: Safety and Efficacy in the Treatment and Prevention of Motion Sickness. Clinical Medicine Insights: Therapeutics.
  5. Kay GG. The effects of antihistamines on cognition and performance. J Allergy Clin Immunol. 2000 Jun;105(6 Pt 2):S622-7.
Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on October 13, 2025. Next review due on October 13, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Bonine Meclizine

How to take Bonine

Chew or crush the tablet before swallowing it. Don’t swallow it whole.

It’s best to take Bonine at the first sign of symptoms, as it can take up to an hour to start working.

Dr Alexandra Cristina Cowell
This page was medically reviewed by Dr Alexandra Cristina Cowell on October 13, 2025. Next review due on October 13, 2028.

How we source info.

When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.

Bonine Meclizine

Bonine isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.

Here’s all the official info on it. If anything is unclear, let our doctor know, and they can talk with you about it.

Bonine Meclizine

Bonine: FAQ

Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.

Can I get Bonine through private health insurance?

Answer:
Private healthcare plans sometimes cover medications like Bonine, but there may be some that only cover specific treatments. So if you’re looking to get Bonine and have private health insurance, check your plan first to make sure it’s covered.

Your insurance may cover a similar medication if Bonine isn’t named. If not, you can always get Bonine from an online prescription and pharmacy service, but you’ll have to pay for this yourself, and it’s unlikely you’ll be eligible for reimbursement.

Can you take Bonine while pregnant?

Answer:
It’s best to check with your doctor whether taking Bonine is right for you when you’re pregnant. Generally, it’s considered safe and doesn’t increase the risk of birth defects.

Will I get side effects from Bonine?

Answer:
There's a risk of getting side effects when taking Bonine, although not everyone will get them. Some side effects include:

  • Drowsiness 

  • Sleepiness

  • Nausea

  • Vomiting

  • Headache


For the full list of side effects, check the package leaflet that comes with your medication. 

Can I drink alcohol while on Bonine?

Answer:
You should avoid drinking alcohol while on Bonine. This is because alcohol may cause or worsen side effects and increase drowsiness.[1]

How long does Bonine take to work?

Answer:
Bonine starts to take effect within an hour.[1] If you take Bonine but it takes longer than this to work, or doesn’t work well for you, let your prescriber know – they may recommend a different treatment.

Treated trusted source:

  1. Patel, P. N., & Ambizas, E. M. (2011). Meclizine: Safety and Efficacy in the Treatment and Prevention of Motion Sickness. Clinical Medicine Insights: Therapeutics.

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