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Last updated on Mar 02, 2025.
Benadryl is a first-generation antihistamine that can help treat insomnia.
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Benadryl is a first-generation antihistamine commonly used to relieve allergy symptoms. It can also be used to treat sleeping problems, such as insomnia, because of its sedating effects, which make you drowsy and tired. It’s taken 20 minutes before bedtime, giving it enough time to take effect and help you achieve a good night’s sleep.
Benadryl isn’t a long-term solution to manage insomnia. It can only provide short-term relief for temporary sleeping issues. Prolonged use can lead to increased tolerance, meaning it will become less effective as your body becomes used to it.
Diphenhydramine, the active ingredient in Benadryl, is a first-generation antihistamine. It works by blocking histamine from binding to the histamine receptors in your brain. Since histamine promotes wakefulness, reduced levels can lead to drowsiness and tiredness.[1]
Benadryl comes in two doses: 25mg and 50mg. The typical dosage for adults is 25mg to 50mg, taken before bedtime.
There are other doses available and forms, like liquid and nasal sprays, but these are used to treat allergy symptoms, not insomnia.
This page was written by The Treated Content Team.
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Swallow the tablet with some water. Take it at bedtime but no more than 30 minutes before going to bed because it can make you drowsy and effect your alertness..
Benadryl should only be used short-term; it shouldn’t be taken for longer than two weeks. If you still have trouble sleeping, let your doctor know.
Benadryl lasts around four to six hours, giving you plenty of time to get a good night’s sleep. You should avoid taking an extra dose if you wake up in the middle of the night, as it could make the side effects worse and make it more difficult to wake up in the morning.
If you accidentally take too much Benadryl, you might experience side effects like confusion or headache. This should go away as the medicine wears off, but if you’re concerned, contact your local medical department.
This page was written by The Treated Content Team.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
