Adapalene is a topical gel that’s used to manage acne. Its name comes from its active ingredient, which belongs to a class of medicines known as retinoids. These help regulate skin cell turnover, break down acne lesions, and unclog pores.
The gel can be used daily to clear blackheads, whiteheads and pimples from your skin. Applying Adapalene regularly can also prevent them from returning, keeping your skin clear and acne-free.
Acne causes the process of skin turnover to happen too fast, meaning the old cells can clog your pores, along with other types of dirt and bacteria. It can have numerous causes — sometimes it’s as simple as genetics, but an increase in testosterone, being pregnant, or reacting to cosmetic products are all known to trigger flare-ups. Adapalene works deep in your pores to clear blockages and prevent them from happening again as your skin heals.
How does Adapalene work?
Retinoids are derived from vitamin A, and work primarily by unclogging pores. They also have an exfoliating effect, removing dead skin cells and other debris from the surface of your skin. They’re a commonly used treatment for acne,[1] and are often used in combination with an antimicrobial formula.
Applying Adapalene each evening can reduce the irritation and redness caused by acne. After washing your face, you usually apply a thin layer of gel to the affected area. By using it in the evening, your skin has the chance to heal without the gel being rubbed off as it would during your daily routine.
Adapalene 0.1% was FDA approved in 2016, and since then has been used in gels, creams and lotions to help manage acne.[2]
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on September 30, 2024. Next review due on September 30, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to use Adapalene for acne
Adapalene is easy to use, which makes it simple to stick to a regular application routine.
First, wash and dry the area you need to treat. Acne commonly occurs on the face,[1] so if that’s where you’re applying it, make sure your cheeks and neck are thoroughly dry and free from any make-up or other skincare products. Adapalene is normally applied in the evenings before you go to bed, but your physician will let you know if you need to use it more often.
Using your fingertip, apply a thin layer of gel to any affected areas, taking care to avoid your eyes and mouth.
Once you’ve finished, wash your hands. If you are using any other skincare products, leave enough time for Adapalene to absorb into the skin and dry naturally before you use them.
Are there different doses of Adapalene?
Adapalene is only available as a 0.1% formula, which usually comes in a 45g tube.
It’s usually advised you use the gel once a day, but a physician might tell you otherwise depending on the severity of your acne symptoms. They might also recommend you use Adapalene alongside another medication if they feel like this will benefit your skin.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on September 30, 2024. Next review due on September 30, 2027.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Adapalene isn’t suitable for everyone, and there are some things that you need to be aware of when using it.
The patient information leaflet that comes with your gel contains all the official info on it. If anything is unclear, let our physician know, and they can talk with you about it.
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Adapalene: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
How long does Adapalene take to clear acne?
Answer:
If you’re using Adapalene, the time it takes to work can vary. People respond differently to medications, and it might depend on how severe your symptoms are. Adapalene gel is usually used for acne that is considered mild to moderate, so if you don’t feel like it’s helping, you might need to try something stronger.
In a study that analyzed Adapalene,[2] the gel generally improved symptoms after 12 weeks. If you’ve been applying Adapalene for that long and your acne isn’t improving though, you should let a physician know.
How well does Adapalene work for acne?
Answer:
In a study of Indian patients who used adapalene 0.1% gel for 12 weeks to manage their acne, 96.3% of participants saw improvements. Of the 441 patients who completed the study, 78% said they found the gel tolerable, rating it either ‘excellent’ or ‘good’.[2]
It was also used by some patients in the study alongside other acne treatments. This suggests Adapalene can be applied as part of a routine that involves different medications designed to improve the condition of your skin. If you are using other acne medications at the same time as Adapalene, let your physician know.
How is Adapalene different from other treatments for acne?
Answer:
Adapalene is a common type of retinoid used for managing acne. Another is tretinoin, which is available in cream and gel formulas. Like Adapalene, it’s usually applied once daily in the evenings.
Other acne treatments, such as benzoyl peroxide, are used to target harmful bacteria and have an antiseptic effect, as well as being anti-inflammatory. These might be recommended if it looks like your skin is infected, although they’re often used sparingly as they can cause skin irritation when overused.
Apart from prescription-strength acne treatments, there are lots of topical lotions and emollients that might be beneficial to you as they can help protect the skin barrier.
Can Adapalene be used for other skin conditions?
Answer:
Topical retinoids are used for multiple skin conditions, such as psoriasis and photoaging. Because they can sometimes help to even out skin tone, they can be prescribed off-label for hyperpigmentation.[3]
But Adapalene is primarily an acne treatment. So if you’re thinking of using it for another skin condition, or one you have another skin condition as well as acne, speak to a physician first to get some professional advice.
Can I only use Adapalene on my face?
Answer:
You can apply Adapalene to any areas of your body affected by acne. The exfoliating effect of the gel should help clear clogged pores wherever you rub it, so it isn’t just limited to your face.
If you’re using the gel on your arms, legs or back though, make sure you leave it long enough to work before putting clothes over it, as this could potentially wipe the gel off and stop it doing its job. It’s generally recommended to let the gel absorb and dry naturally before covering the area with clothes or other products.
Can I use Adapalene if I’m pregnant?
Answer:
Topical retinoids won’t generally be prescribed to you if you’re pregnant. This is because there’s a risk they could lead to birth defects.
If you’re trying to manage acne during pregnancy, a doctor can suggest some safe options you can try that they think are less likely to cause a risk to your baby’s health.
Do I need a prescription for Adapalene?
Answer:
You can get Adapalene over the counter. Previously, it was only available with a prescription.
Getting acne treatments from online pharmacies gives you a chance to talk to a medical professional who can make sure it’s a suitable medication for you.
It’s best to always be sure medications and products you see on the shelves of supermarkets and stores are safe before you use them to manage your acne. Read the active ingredient list thoroughly to check they don’t contain anything that might make your symptoms worse.
Percy, S. (2003). Safety and efficacy of adapalene gel 0.1% in acne vulgaris: Results of a post-marketing surveillance study. Indian Journal of Dermatology, Venereology and Leprology.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Sep 30, 2024
Published by: The Treated Content Team.Medically reviewed by: Dr. Joseph Palumbo, Senior Medical Adviser
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Dr. Joseph Palumbo
Senior Medical Adviser
Joseph joined Treated in 2023, and is one of the lead doctors providing prescribing services for the platform.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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