Acyclovir is a non-branded version of Zovirax. Because it’s a generic medication, it’s usually a little cheaper, but the results it offers are exactly the same. Acyclovir is normally prescribed to treat infections caused by the herpes virus. It helps to remove the visible symptoms caused by the infection and leaves your skin looking nice and clear. You might see this medication used to treat other viruses like shingles or chickenpox.
The cream version is usually prescribed to treat cold sores, whereas the tablets are prescribed to tackle herpes or genital herpes directly. You can also get Acyclovir as an injection, but this is usually administered in a hospital.
How does Acyclovir work?
Acyclovir is named after its active ingredient, acyclovir, which acts by inhibiting viral DNA replication. By doing this, it reduces the severity of the infection and stops the virus from spreading.
Although acyclovir won’t cure herpes, it does help relieve the pain and discomfort, and helps the sores (if any) heal faster. As well as treating current outbreaks, Acyclovir can also help prevent future ones.[1]
What doses of Acyclovir are there?
There are only two dosage options available for Acyclovir. For the tablet version it’s a 200 mg tablet, and for the cream it’s one tube that contains 5% of the active ingredient, acyclovir.
Treated trusted source:
Cernik, C. (2008). The Treatment of Herpes Simplex InfectionsAn Evidence-Based Review. Archives of Internal Medicine, [online] 168(11), p.1137
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on February 20, 2025. Next review due on February 20, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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How to take Acyclovir
The 200 mg tablets should be taken five times per day for up to five days to treat a recurring herpes outbreak. The cream can typically be applied around five times per day to the area of the cold sore. If you don’t notice any visible improvements at the end of this period then talk with our doctor for further assistance.
We always recommend taking this medication as advised by our doctor for the best results. However, if you have any questions you can always refer to the treatments package insert. This should be included in the box with your medication.
Acyclovir tablet instructions
Dissolve the tablet in a glass of water and stir before drinking.
If you prefer, the tablet can also be swallowed whole with water.
Take your tablets as soon as you notice an outbreak
The dose that you should take will depend on the condition that you have been prescribed Acyclovir for. Our physician will discuss this with you.
If you’re taking multiple tablets a day, keep at least four hours between each dose.
Acyclovir cream instructions
Use the cream as soon as you notice a cold sore forming.
Gently rub the cream on the affected area.
Let your skin absorb the cream. Do not wash the cream away with water.
How long does it take Acyclovir to work?
Treatment time can vary depending on you and the severity of your infection. You should start to feel the positive effects of Acyclovir within five days of starting your course. If you don’t feel any positive benefits after five days, send our doctor a message.
What should I do if I make a mistake when taking Acyclovir?
Acyclovir isn’t usually harmful. But you should avoid taking too much of it over several days. If you have taken too much, you should contact our physician or a healthcare professional for further advice as soon as you can. Be sure to bring your product box and leaflet with you if they ask you to visit them for an appointment.
What if I forget to take Acyclovir?
If you forget to take a dose of Acyclovir 200 mg, just take a tablet as soon as you remember.
If you remember once your next dose is due, then just skip the forgotten dose and continue with your treatment as normal.
Don’t take a double dose to make up for a missed tablet.
This page was written by The Treated Content Team.
This page was medically reviewed by Dr. Joseph Palumbo on February 20, 2025. Next review due on February 20, 2028.
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Acyclovir isn’t suitable for everyone, and there are some things that you need to be aware of when taking it.
Here’s all the official info on it. If anything is unclear, let our clinician know, and they can talk with you about it.
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Acyclovir: FAQ
Have something specific you want to know? Search our info below, or ask our experts a question if you can’t find what you’re looking for.
How is Acyclovir different to other herpes medications?
Answer:
Most forms of antiviral treatment for herpes and cold sores contain a very similar type of active ingredient. The main difference is that not all of them are available as creams and oral suspensions like Acyclovir is.
Is Acyclovir similar to any other medicines?
Answer:
Acyclovir is the generic, non-branded version of Zovirax. They both contain the same active ingredient so they work in exactly the same way. The main difference with brand products is that they can be a little more expensive than generic medicines.
Because Zovirax is made by a specific company, it’s classed as a branded product. Some people prefer to use brand names because they prefer them whereas others are happier with a med that’s essentially the same but cheaper.
What type of Acyclovir should I use?
Answer:
For cold sores, you’re usually better off using Acyclovir 50 mg cream. The tablets are better suited for dealing with genital herpes and work to prevent future outbreaks from occurring. Our doctors can advise you on which treatment is the right option for you.
How effective is Acyclovir?
Answer:
A 2002 clinical study into the effectiveness of Acyclovir showed that it is highly effective at clearing up the symptoms of herpes and stopping recurring outbreaks. The study was undertaken on a mixed-sex group of 131 adults who were infected with the herpes virus.[1] The average duration of lesions was four days for the group who were given Acyclovir as treatment. The group who were given the placebo version (a fake tablet) suffered from lesions for up to six days. This shows that Acyclovir is effective at reducing the time taken for symptoms of genital herpes to clear up.
It is worth noting that Acyclovir doesn't kill the herpes virus, it just stops it from spreading. The herpes virus still inhabits your body once this medication is taken, Acyclovir just stops it from multiplying. [1]
Do I need a prescription for Acyclovir?
Answer:
Yes, you will need a prescription for Acyclovir. This is just to make sure that the medicine is safe and right for you before taking it. Herpes is hard to treat, so it’s always worth speaking with a medical professional before deciding which medication is right for you.
Our experts continually monitor new findings in health and medicine, and we update our articles when new info becomes available.
Feb 20, 2025
Published by: The Treated Content Team.Medically reviewed by: Dr. Joseph Palumbo, Senior Medical Adviser
How we source info.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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Dr. Joseph Palumbo
Senior Medical Adviser
Joseph joined Treated in 2023, and is one of the lead doctors providing prescribing services for the platform.
When we present you with stats, data, opinion or a consensus, we’ll tell you where this came from. And we’ll only present data as clinically reliable if it’s come from a reputable source, such as a state or government-funded health body, a peer-reviewed medical journal, or a recognised analytics or data body. Read more in our editorial policy.
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