Chantix

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Medically reviewed by
Mr Craig Marsh
Clinical Reviewer
on Oct 18, 2024.
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Last updated on Sep 24, 2025.

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What side effects can you get from Varenicline?

Although Varenicline can cause side effects for many people, it’s important to note that so too does the very act of quitting smoking (known as withdrawal symptoms). Many people who quit smoking experience weight gain, increased irritability, nausea, and flu-like symptoms. Taking smoking cessation drugs such as Varenicline can help lessen these withdrawal effects and make the process of giving up nicotine more achievable and successful in the long run. So any side effects you may feel with Varenicline might not be a direct result of the medication, or might actually be worse if you weren’t taking it.

When used successfully, Varenicline can help you lead a smoke-free life, but be aware that it can cause side effects itself, ranging from mild to severe. If you are concerned about any of the listed side effects of Varenicline, don’t hesitate to reach out to your prescriber.

  • Very common

  • Common

  • Uncommon

  • Rare

  • Unknown

The most common side effects (which may affect more than 1 in 10 people taking Varenicline) include;

  • Inflammation of the nasal passages
  • Abnormal dreams
  • Headaches
  • Nausea
  • Insomnia.

These side effects may affect up to 1 in 10 people, they include:

  • Chest infections
  • Sinuses inflammation
  • Appetite changes
  • Dizziness
  • Change of taste
  • Sleepiness or tiredness
  • Heartburn
  • Coughing
  • Constipation
  • Diarrhea
  • Bloating
  • Toothache
  • Flatulence
  • Skin itching
  • Chest pain
  • Dry mouth

Less common side effects (affecting up to one in 100 people) include; 

  • Fungal infection
  • Viral infection
  • Difficulty thinking
  • Restlessness
  • Mood swings
  • Depression
  • Anxiety
  • Hallucinations
  • Changes in sex drive
  • Seizure
  • Feeling sluggish
  • Less sensitive to touch
  • Eye infection or pain
  • Ringing in the ears
  • Angina
  • Changes in heart rate
  • Increased blood pressure
  • Hot flush
  • Inflammation of nose, sinuses and throat
  • Congestion of nose, throat, and chest
  • Hoarseness
  • Hay fever
  • Excess mucus from nose causing cough
  • Runny nose
  • Red blood in stools
  • Irritated stomach
  • Change of bowel habit
  • Belching
  • Mouth ulcers
  • Pain in the gums
  • Skin reddening
  • Acne
  • Increased sweating
  • Muscle spasms
  • Chest wall pain
  • Abnormally frequent urination
  • Increased menstrual flow
  • Chest discomfort
  • Flu-like illness
  • Fever
  • Feeling weak or unwell
  • High blood sugar
  • Heart attack
  • Suicidal thoughts
  • Changes in thinking or behavior (such as aggression)

Rare side effects of taking Varenicline include 

  • Excessive thirst
  • Slow thinking
  • Altered sleep pattern
  • Stroke
  • Increased muscle tension
  • Difficulty with speech and coordination
  • Reduced sense of taste
  • Visual disturbances
  • Blood in vomit, abnormal stools, coated tongue
  • Stiff joints
  • Rib pain
  • Glucose in urine
  • Vaginal discharge
  • Feeling cold
  • Cyst
  • Diabetes
  • Sleep walking
  • Psychosis
  • Abnormal behavior
  • Severe skin reactions

These affect up to one in a 1000 users of Varenicline.

Whilst it is still unknown what the effects might be, it’s not advised to take Chantix during pregnancy or nursing an infant due to the potential for the drug to be transferred to the fetus or the child.

Varenicline : serious side effects

It’s important to be aware of the more serious side effects of Varenicline before you decide to begin treatment. If you’re concerned about them, consult your doctor to discuss these concerns further.

Many of the serious side effects of Varenicline occur infrequently. Seeking the help or advice of a medical professional will help reassure you on what is best for you and will help you weigh up the benefits over the risks.

Varenicline and alcohol side effects

While some prescribers may not actively advise against drinking alcohol whilst taking Varenicline, there is still a chance that the two substances can negatively interact.

Some people who have mixed alcohol and Varenicline have reported that their tolerance for alcohol is much lower, and they get more drunk, more easily. Additionally, they report that their potential for alcohol-induced blackouts increases, and they can become aggressive or rowdy more easily. At the very least, it’s wise to limit alcohol intake while using Varenicline.

That said, some studies have suggested that varenicline can help people with alcohol dependency to drink less, by reducing your cravings the same way it does with nicotine. However there’s not a great deal of evidence to back this up.

Can Varenicline cause weight gain?

One of the potential side effects of Varenicline that causes people some concern is weight gain. However, it’s worth noting that quitting smoking can cause weight gain on its own. This is because smoking suppresses appetite and speeds up metabolism.
Additionally, while weight gain is listed as a potential side effect of Varenicline, very few people do actually put on weight whilst taking the treatment. In fact, some studies regarding Varenicline weight gain have shown that users do not gain more weight on Varenicline than without.

Does Varenicline cause constipation?

In some cases, Varenicline can cause adverse gastrointestinal effects, such as constipation, but this is quite an uncommon side effect. Quitting smoking can also cause constipation, it’s not always easy to work out the underlying cause. One study showed that one in 24 subjects treated with varenicline (the main ingredient found in Varenicline) experienced constipation.

Can Varenicline cause loss of libido?

A concern amongst many individuals thinking about taking Varenicline is the prospect of a loss of libido.

However, a decreased libido is a rare side effect experienced by roughly one in 1000 users of Varenicline. Additionally, in those rare cases that Varenicline does affect sex drive, it can also lead to an increased libido.

Can Varenicline cause sleep problems?

It has been reported that Varenicline can cause issues with sleep. However, it’s important to remember that restlessness and difficulty sleeping can also be generic symptoms of nicotine withdrawal.

Some studies have found that abnormal dreams and sleeping patterns are common side effects of taking varenicline, but these symptoms often subside after the first few weeks after beginning treatment. Taking your evening dosage immediately after your evening meal and not straight before bedtime can help reduce the sleep-related side effects of Varenicline.

That said, it’s essential to talk to one of our doctors or consult your family practitioner if you feel these symptoms becoming more extreme or if you begin to experience sleep aggression or sleepwalking.

How long do Varenicline side effects last?

A usual course of Champix lasts for around 12 weeks, and side effects are most common during the first few weeks.

However, while most side effects of varenicline are temporary and should resolve after treatment, some serious side effects have been reported to last longer. These are typically neuropsychiatric issues, like depression or mood changes. In rare cases, these problems can persist even after you stop taking the medication. It’s really important to discuss any severe or lasting side effects with your doctor.

What happens when you stop taking Varenicline

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People who suddenly discontinue their Varenicline treatment may experience some side effects or withdrawal symptoms. Varenicline withdrawal side effects may include feelings of depression, irritability, difficulty sleeping, and the urge to smoke again, leading to a potential relapse.

For this reason, if you wish to stop your Varenicline treatment, your doctor may advise that you gradually reduce your dosage over a week or two.

What to do if you experience Varenicline side effects

If you experience any side effects whilst taking Varenicline, you should inform your prescribing doctor immediately. As discussed, the side effects of suddenly stopping Varenicline can cause relapses, so it’s best to discuss your options with a clinician before stopping treatment.

If you are prescribed Varenicline but find that it does not work for you for whatever reason, your prescribing doctor will be able to find alternative stop smoking treatments for you. There are plenty of other medical aids available which can help you kick smoking successfully.

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This page was medically reviewed by Mr Craig Marsh, Clinical Reviewer on Oct 18, 2024. Next review due on Oct 18, 2027.

Last updated on Sep 24, 2025.

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